בשל "הגנת זכויות יוצרים", מובא להלן קישור למאמר בלבד. לקריאתו בטקסט מלא, אנא פנה לספרייה הרפואית הזמינה לך.

Is the risk of bleeding requiring a return to the operating room when ibuprofen is used for postoperative analgesia after pediatric tonsillectomy with or without adenoidectomy no worse than the risk of bleeding when acetaminophen is used for
postoperative pain management?

In this randomized, multicenter, double-blind, noninferiority clinical trial that included 741 children, the rate of bleeding requiring operative intervention was 1.2% in the acetaminophen group and 2.9% in the ibuprofen group.

The criteria to conclude that ibuprofen is noninferior to acetaminophen were not met.

Ibuprofen may increase the risk of severe bleeding after tonsillectomy with or without adenoidectomy; further work is needed to understand if shorter duration or combination therapy reduce this risk.